<p>(<b>A</b>) DHX29 stably transfected (mDHX29) MEFs were infected with EMCV (multiplicity of infection [MOI] 5) or VSV (MOI 0.5). EMCV and VSV mRNA levels by real-time PCR analysis and virus titers were determined. Virus titers were expressed as plaque-forming units (pfu)/ml. (<b>B</b>) EMCV and VSV mRNA levels and titers were determined in scrambled (Scr) siRNA- and <i>DHX29</i> siRNA-transfected MEFs 24 h post-infection with EMCV (MOI 5) or VSV (MOI 1). (<b>C</b>) MDA5-knockout (<i>MDA5-/-</i>) and WT MEFs and (<b>D</b>) RIG-I-knockout (<i>RIG-I-/-</i>) and WT MEFS were transfected with <i>DHX29</i> siRNA or Scr siRNA and then infected with EMCV or VSV at the indicated MOIs. IFN-β production was determined by ELISA. Data from (<b>A-D</b>...
<p><b>A.</b> Heatmap displaying 22 genes induced upon WNV infection in <i>Ifnar<sup>−/−</sup></i> mD...
<p>FL cells were transfected with targeting siRNA (PKR si, MAVS si, or RIG-I si) or nontargeting con...
<p>WT and <i>Ifnar1<sup>−/−</sup></i> BMDCs were infected with SeV Cantell HD (HD), SeV Cantell LD (...
<p>(<b>A</b>) Human PBMCs, (<b>B</b>) murine BMDCs, and (<b>C</b>) murine peritoneal macrophages (pM...
<p>(<b>A</b>) Whole cell lysates (WCL) obtained from 293T cells cotransfected with <i>HA-DHX29</i> a...
Melanoma differentiation-associated gene-5 (MDA5) recognizes distinct subsets of viruses including E...
<div><p>Melanoma differentiation-associated gene-5 (MDA5) recognizes distinct subsets of viruses inc...
<p>(A) Loss of mDDX24 affects VSV-luc replication in MEFs. MEFs transfected with ns, mDDX24 or RIG-I...
<p>Human A549 cell lines with constitutive knockdown of PKR (shPKRA549) or a control (shControl A549...
DEAD (Asp-Glu-Ala-Asp)-box RNA helicases (DDX) play important roles in viral infection, either as cy...
<p>LSECs were treated with medium ± IFNβ (500 U/mL) and 24 h later infected with MCMV WT. Virus abso...
<p><b>A</b> and <b>B</b>, Wild-type (WT) MEFs and Mfn1 or Mfn2-knockout MEFs were infected with NDV ...
<p>(<b>A</b>) Schematic of DHX29 truncated forms (<i>top panel</i>). 293T cells were transfected wit...
<p>(<b>A</b>) 293T cells and (<b>B</b>) 293T-TLR3 cells were cotransfected with IFN-β or ISRE promot...
<p>DDX3 ko-1, DDX3 ko-2 and WT A549 cells were infected with LCMV Cl13 (M.O.I. 0.5) for the indicate...
<p><b>A.</b> Heatmap displaying 22 genes induced upon WNV infection in <i>Ifnar<sup>−/−</sup></i> mD...
<p>FL cells were transfected with targeting siRNA (PKR si, MAVS si, or RIG-I si) or nontargeting con...
<p>WT and <i>Ifnar1<sup>−/−</sup></i> BMDCs were infected with SeV Cantell HD (HD), SeV Cantell LD (...
<p>(<b>A</b>) Human PBMCs, (<b>B</b>) murine BMDCs, and (<b>C</b>) murine peritoneal macrophages (pM...
<p>(<b>A</b>) Whole cell lysates (WCL) obtained from 293T cells cotransfected with <i>HA-DHX29</i> a...
Melanoma differentiation-associated gene-5 (MDA5) recognizes distinct subsets of viruses including E...
<div><p>Melanoma differentiation-associated gene-5 (MDA5) recognizes distinct subsets of viruses inc...
<p>(A) Loss of mDDX24 affects VSV-luc replication in MEFs. MEFs transfected with ns, mDDX24 or RIG-I...
<p>Human A549 cell lines with constitutive knockdown of PKR (shPKRA549) or a control (shControl A549...
DEAD (Asp-Glu-Ala-Asp)-box RNA helicases (DDX) play important roles in viral infection, either as cy...
<p>LSECs were treated with medium ± IFNβ (500 U/mL) and 24 h later infected with MCMV WT. Virus abso...
<p><b>A</b> and <b>B</b>, Wild-type (WT) MEFs and Mfn1 or Mfn2-knockout MEFs were infected with NDV ...
<p>(<b>A</b>) Schematic of DHX29 truncated forms (<i>top panel</i>). 293T cells were transfected wit...
<p>(<b>A</b>) 293T cells and (<b>B</b>) 293T-TLR3 cells were cotransfected with IFN-β or ISRE promot...
<p>DDX3 ko-1, DDX3 ko-2 and WT A549 cells were infected with LCMV Cl13 (M.O.I. 0.5) for the indicate...
<p><b>A.</b> Heatmap displaying 22 genes induced upon WNV infection in <i>Ifnar<sup>−/−</sup></i> mD...
<p>FL cells were transfected with targeting siRNA (PKR si, MAVS si, or RIG-I si) or nontargeting con...
<p>WT and <i>Ifnar1<sup>−/−</sup></i> BMDCs were infected with SeV Cantell HD (HD), SeV Cantell LD (...