Hematopoietic deficiency of HIC1 results in susceptibility to <i>Citrobacter rodentium</i> infection.

<p><i>Hic1</i>^<i>Vav</i> and <i>Hic1</i>^<i>fl/fl</i> mice were orally inoculated with <i>C</i>. <i>rodentium</i>. (A) Weight loss (percentage of initial weight) was calculated for each mouse over course of infection. (B, C) Bacterial loads (CFU/g) from fecal pellets (B) and liver (C) were measured at 11 days post inoculation. (D) Quantitative RT-PCR was performed to determine expression of <i>Il17a</i>, <i>Il22</i> and <i>Reg3g</i> from distal colon tissue 11 days post inoculation. Data are pooled from 2 independent experiments (<i>n</i> = 8–9 per group). *, P < 0.05; **, P < 0.01; Mann-Whitney test. Error bars indicate SEM. nd, none detected.