<i>Hic1</i> expression in T cells and dendritic cells is not required for immunity to <i>Citrobacter rodentium</i> infection.

<p>(A–C) <i>Hic1</i>^<i>CD4</i> and <i>Hic1</i>^<i>fl/fl</i> mice were orally inoculated with <i>C</i>. <i>rodentium</i>. (A) Weight loss (percentage of initial weight) was calculated for each mouse over course of infection. (B) Bacterial loads (CFU/g) from fecal pellets were measured over course of infection. (C) Quantitative RT-PCR was performed to determine expression of <i>Il17a</i>, <i>Il22</i> and <i>Reg3g</i> from distal colon tissue 14 days post inoculation. (D–F) <i>Hic1</i>^<i>CD11c</i> and <i>Hic1</i>^<i>fl/fl</i> mice were orally inoculated with <i>C</i>. <i>rodentium</i>. (D) Weight loss (percentage of initial weight) was calculated for each mouse over course of infection. (E) Bacterial loads (CFU/g) from fecal pellets were measured over course of infection. (F) Quantitative RT-PCR was performed to determine expression of <i>Il17a</i>, <i>Il22</i> and <i>Reg3g</i> from distal colon tissue 11 days post inoculation. (A-C) Data are pooled from 3 independent experiments (<i>n</i> = 7–11 per group). (D-F) Data are pooled from 2 independent experiments (<i>n</i> = 4–5 per group) *, P < 0.05; Mann-Whitney test. Error bars indicate SEM. ns, not significant.