Enantioselective Organocatalyzed Direct α‑Thiocyanation of Cyclic β‑Ketoesters by <i>N</i>‑Thiocyanato­phthalimide

A new electrophilic thiocyanation reagent, <i>N</i>-thiocyanatophthalimide, was synthesized and applied to the first example of catalytic asymmetric electrophilic α-thiocyanation of various cyclic β-ketoesters by the bifunctional cinchona alkaloid catalysis. Thus, a variety of chiral α-thiocyanato β-ketoesters with a quaternary carbon center have been achieved in excellent yields (up to 99%) and high enantioselectivities (up to 94% <i>ee</i>) in a convenient manner