AZD9977 and eplerenone protect against aldosterone and high salt induced renal injury.

<p>Uni-nephrectomised rats with an aldosterone mini-pump and on a high salt diet were treated for 4 weeks with AZD9977 or eplerenone as food admixtures. Doses in mg kg^-1 d^-1 are indicated under the bars. (a) UACR was measured in urine collected for 24h at day 28. (b) UACR vs free steady average plasma drug exposure normalized to rat <i>in vitro</i> IC₅₀ (C_uss-average/<i>in vitro</i> IC₅₀). Drug exposure levels correspond to the exposure levels achieved at the studied doses (a). c) Renal pathology scores (renal fibrosis and glomerular nephritis). d) Histological sections stained with PAS.Representative photomicrographs of glomeruli/tubular sections from rats treated with vehicle (V), AZD9977 at 10 (AZ 10), 30 (AZ 30) or 100 mg kg^-1 d^-1 (AZ 100) or eplerenone at 10 (EP 10) or 30 mg kg^-1 d^-1 (EP 30). The scale bar corresponds to 200 μm original size. Average +/- SEM; <i>n</i> = 7–8; *p<0.05 compared to vehicle.