Transcriptional modification of expression of radiation-responsive genes in head and neck patients.

<p>Transparent symbols represent QRT-PCR fold change in expression of the genes PHPT (A), CCNG1 (B), CDKN1A (C), GADD45 (D), and SESN1 (E) for eight head and neck cancer patients before (0) and after 1, 2, and 25 fractions of radiotherapy (RT). The mean (± SEM) is shown as non-transparent symbols. Gene expression is given as fold change relative to unexposed Control sample set at 1 (normalized against the housekeeping gene, HPRT). **, statistically significant difference versus Control group (p < 0.01); ***, statistically significant difference versus Control group (p < 0.005). For GADD45 p-trend was applied (r² = 0.980).