Induction and persistence of different biomarkers.

<p>Graphs showing the induction and temporal persistence of the biomarkers studied in endometrial (A) and head and neck patients (B). In order to compare all the parameters studied, the highest value detected was arbitrary set as 100%. Established cytogenetic markers and mtDNA content are suitable for late time points after irradiation while the new biomarkers as radiation-induced genes are more informative atearly time-points after radiation exposure. mt Maj, data from mtDNA content analysis of mtMajArch; mt Min, data from mtDNA content analysis of mtMinArch; gene expression, data from MQRT-PCR (average of five genes); micronuclei, data from micronuclei assay; aberrations, data from structural aberration analyses; dicentrics, data from dicentric chromosomes assay; apoptosis, data from flow-cytometric detection of apoptotic cells in lymphocyte population (percentage of apoptotic cells versus healthy-intact cells set as 100%).