Probiotic Potential of <i>Pediococcus pentosaceus</i> LJR1, a Bacteriocinogenic Strain Isolated from Rumen Liquor of Goat (<i>Capra aegagrus</i> hircus)

<p>In present study, we evaluated the probiotic potential of three potent antibacterial <i>Pediococcus pentosaceus</i> isolates, viz., LJR1, LJR5, and LJR9 from the rumen liquor of a healthy goat and compared to a commercial probiotic, <i>Lactobacillus rhamnosus</i> GG NCDC 347. All the three isolates exhibited broad-spectrum of antibacterial activity against food borne pathogens. Among the isolates <i>P. pentosaceus</i> LJR1 strain was found to tolerate acid, bile, simulated gastric, and intestinal juice comparable to a standard strain and also showed strong adhesion to the human colon cancer (HCT-15) cells and prevented adhesion of <i>Listeria monocytogenes</i>. Furthermore, the <i>P. pentosaceus</i> LJR1 showed strong anti-inflammatory properties in the LPS-inflamed human peripheral blood mononuclear cells (PBMCs). The <i>P. pentosaceus</i> LJR1 showing potent antibacterial activity and all the desirable attributes of probiotic bacteria can be utilized as a candidate for the development of probiotic foods and deserves to be exploited for human and animal use.