Additional file 5: of Mitochondrial damage and “plugging” of transport selectively in myelinated, small-diameter axons are major early events in peripheral neuroinflammation

Video S5. High-power time-lapse video of axonal mitochondria labeled with TMRM immediately following laser-induced phototoxic damage to mitochondria. The side of the imaging field left to the white line was not exposed to photo-toxic damage. The imaging field to the right of the white line was exposed to laser-induced photo-toxic damage, using the red laser to specifically damage functional mitochondria. Notably, the number of mobile mitochondria transported into the area exposed to photo-toxic damage appears overwhelmingly biased in the favor of anterograde movement. (AVI 2466Â kb