Work flow of the study.

<p>(A+B) 1804 Gene expression profiles (GEP) of patients with Diffuse Large B-cell Lymphoma from 20 studies were collected from the gene expression omnibus (GEO). (C) CD20 (gene: MS4A1), as a central protein in B-cell receptor (BCR) signaling and key target for the treatment of DLBCL, was chosen to perform a guilt-by-association analysis. Genes outside the context of BCR signaling (indicated by the grey dots) were chosen for drug-gene prioritization. (D) The Drug Gene Interaction database (DGIdb), Pubmed and clinicaltrials.gov were used to identify drug-gene targets that were not clinically studied in DLBCL before. (E) Two drug-gene targets were chosen for proof-of-concept in vitro studies.