Plasma myeloperoxidase (MPO) levels and activity are unchanged in coronary artery disease patients in China.

<p>Plasma MPO levels in subjects with coronary artery disease (CAD) and without CAD (Non CAD) are represented by box plots of (A) All subjects (n = 40/group), (B) Low HDL subjects alone (n = 20/group) and (C) High HDL subjects alone (n = 20/group). MPO activity is represented by high density lipoprotein (HDL) 3-chlorotyrosine and 3-nitrotyrosine levels normalized to tyrosine levels determined by tandem mass spectrometry. Box plots display the distributions of HDL levels (log scale; log) of 3-chlorotyrosine in (D) All subjects (n = 40/group), (E) Low HDL subjects only (n = 20/group) and (F) High HDL subjects only (n = 20/group) between CAD and Non CAD groups. HDL 3-nitrotyrosine levels represented by box plot (log scale, log) of (G) All subjects (n = 40/group), (H) Low HDL subjects only (n = 20/group), and (I) High HDL subjects only (n = 20/group) between CAD and Non CAD groups. The plasma levels of MPO were not different between CAD and Non CAD subjects in the different cohorts. The HDL 3 chlorotyrosine levels were not different between groups except in the Low HDL subjects were the HDL 3-chlorotyrosine levels were elevated in the CAD subjects than in the non CAD subjects. The HDL 3-nitrotyrosine levels were elevated in the CAD subjects in the entire cohort and in both the low and high HDL subjects. The length of the box defines the interquartile range (IQR). Medians are reported for each group on the raw scale above the respective bar graphs. *denotes p<0.05.