Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections - Fig 1

<p><b><i>In vitro</i> neutralization data for individual antibodies against A, C & D subtype pseudovirus panels.</b> (A) Distribution of HIV-1 subtypes in sub-Saharan Africa using the “Geography Search Interface” on the Los Alamos HIV Database. (B-D) Experimental IC₈₀ titers for antibodies against subtype C, A and D panels, respectively. Viruses are represented on rows and antibodies on columns. Red-yellow shades indicate more-less potent neutralization, and blue cells indicate IC₈₀ titers above experimental threshold or 10μg/ml. (E) Comparison of IC₈₀ distributions for each antibody across subtypes. The percent of viruses in each subtype with IC₈₀ above experimental threshold for each antibody are indicated in the figure. The IC₈₀ distributions between subtypes were compared for each antibody using Wilcoxon rank sum test and comparisons with p < 0.01 are indicated.