<p>Box plots represent the estimated probability of resistance to (<b>a</b>) Rituximab in normal B-cell subsets, (<b>b</b>) Rituximab in all CLL samples, (<b>c</b>) Cyclophosphamide in normal B-cell subsets and (<b>d</b>) Cyclophosphamide in all CLL samples. The global <i>P</i>-value for equal mean resistance probability was < 0.001 in all four cases. Color codes as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0193249#pone.0193249.g001" target="_blank">Fig 1</a>.</p
<p>1×10∧3 bulk of tumor cells or CSLCs plated in 5 replicas into 96-well plates were challenged for ...
<p>Blue = responsive, red = fully refractory, brown = early progression, grey = early death. No Ritu...
<p>(<b>A</b>) 435s/M14 melanoma and (<b>B</b>) BT-549 breast cancer cells were treated with doxorubi...
<p>(A) The probability of developing resistance during continuous therapy as a function of the growt...
<p>Boxplots indicate the distribution of drug sensitivity values (based on IC50) in each cancer line...
<p>(A) We show the probability of resistance during pulsed therapy as a function of the growth rate ...
2: resistance undetermined (data were fitted without resistance, but models including more than 10% ...
<p>The probability that resistance is detected for the first time in the first, second or third year...
<p>Each CRC represents the average response of multiple samples testing with error bars demonstratin...
<p>(a) The dose-response curves for the wild type in blue (<i>r</i>(<i>c</i>) = 0.6(1−tanh(15(<i>c</...
At the beginning of treatment the population consists of the sensitive strain at its carrying capaci...
The mechanism of resistance of tumor cells to chemotherapeutic agents is explored using probabilisti...
Drug resistance in cancer refers to recurrent or primary refractory disease following drug therapy. ...
International audiencecenter dot Serum concentrations of rituximab influence its clinical efficacy i...
kill of non-resistant cycling cells score 5: highest cell kill). Colours refer to the type of model ...
<p>1×10∧3 bulk of tumor cells or CSLCs plated in 5 replicas into 96-well plates were challenged for ...
<p>Blue = responsive, red = fully refractory, brown = early progression, grey = early death. No Ritu...
<p>(<b>A</b>) 435s/M14 melanoma and (<b>B</b>) BT-549 breast cancer cells were treated with doxorubi...
<p>(A) The probability of developing resistance during continuous therapy as a function of the growt...
<p>Boxplots indicate the distribution of drug sensitivity values (based on IC50) in each cancer line...
<p>(A) We show the probability of resistance during pulsed therapy as a function of the growth rate ...
2: resistance undetermined (data were fitted without resistance, but models including more than 10% ...
<p>The probability that resistance is detected for the first time in the first, second or third year...
<p>Each CRC represents the average response of multiple samples testing with error bars demonstratin...
<p>(a) The dose-response curves for the wild type in blue (<i>r</i>(<i>c</i>) = 0.6(1−tanh(15(<i>c</...
At the beginning of treatment the population consists of the sensitive strain at its carrying capaci...
The mechanism of resistance of tumor cells to chemotherapeutic agents is explored using probabilisti...
Drug resistance in cancer refers to recurrent or primary refractory disease following drug therapy. ...
International audiencecenter dot Serum concentrations of rituximab influence its clinical efficacy i...
kill of non-resistant cycling cells score 5: highest cell kill). Colours refer to the type of model ...
<p>1×10∧3 bulk of tumor cells or CSLCs plated in 5 replicas into 96-well plates were challenged for ...
<p>Blue = responsive, red = fully refractory, brown = early progression, grey = early death. No Ritu...
<p>(<b>A</b>) 435s/M14 melanoma and (<b>B</b>) BT-549 breast cancer cells were treated with doxorubi...