High worm burdens and worm biomass are associated with decreased proportions of Th2 and increased proportions of Th1 cells in LPMCs of <i>Trichuris muris–</i>infected mice.

<p>(<b>A</b>) A Spearman’s correlation was performed between worm burden and the proportion of CD4+ cells that are producing IL-13 and IFNγ from LPMCs of infected mice in the laboratory and outdoor enclosure at 3 weeks p.i. (<b>B</b>) A Spearman’s correlation was performed between worm biomass and the proportion of CD4+ cells that are producing IL-13 and IFNγ from LPMCs of infected mice in the laboratory and outdoor enclosure at 3 weeks p.i. Data on cytokine-positive lamina propria cells were log(x+1) transformed to meet assumptions of analysis. These correlations were all significant (<i>P</i> < 0.05) with <i>P</i> values and <i>r</i> values shown on graphs. White circles = Lab; gray triangles = Short-term Wild; black squares = Long-term Wild. <a href="https://doi.org/10.5061/dryad.h9g697r" target="_blank">https://doi.org/10.5061/dryad.h9g697r</a>. IFNγ, interferon-gamma; IL, interleukin; LPMC, lamina propria mononuclear cell; p.i., postinfection; Th1, type 1; Th2, type 2.