Gait phenotypes in paediatric hereditary spastic paraplegia revealed by dynamic time warping analysis and random forests - Fig 1

<p>A) Dendrogram obtained from hierarchical clustering analysis of gait cycles of HSP patients. The vertical axis represents the distance DTW. A vertical line that reaches the base indicates each cycle. Horizontal lines that interconnect the vertical ones indicate DTW distances between the cycles. The higher the horizontal lines joining two cycles, the less similar they are. The lower bar indicates whether the classified cycle is from the right limb (red) or the left (green). Six clusters and an “outlier” (pink cycle) are detected. The majority of cycles are grouped within the red and the blue cluster. B) The <i>heatmap</i> presents Z-scores (standardized comparison to healthy average value) of the spatio-temporal parameters (rows) of each HSP cycle (columns). Green colour indicates a higher spatio-temporal value in the cycle than in healthy children and red, a lower value. The more intense the colour of the square, the further the value of the cycle is from healthy controls. In comparison to healthy controls, red, blue and brown patterns represent less impaired spatio-temporal performance; while orange, green and part of the cycles from the purple pattern show more altered values.