Hepatic gene expression related to inflammation, fibrogenesis and cholesterol metabolism.

<p>Relative mRNA expressions compared with isocaloric diet fed controls of <i>TNF</i> and <i>COL1A1</i> (Panel A), <i>TGFB1</i> and <i>PPARG</i> (Panel B), <i>SREBF2</i>, <i>LDLR</i>, <i>HMGCR</i> and <i>ABCA1</i> (Panel C) and <i>INSIG1</i>, <i>SRB1</i>, <i>GNMT</i> and <i>NPC2</i> (Panel D) in isocaloric controls, high-fat-high-cholesterol (HFHC) controls, two-week NPC2 (treatment) and four-week NPC2 (prevention) animals. Bars represent median ± interquartile range. *: P < 0.05 compared with Isocaloric Controls. **: P < 0.005 compared with Isocaloric controls. ***: P < 0.0005 compared with Isocaloric controls. #: P< 0.05 compared with HFHC Controls. ¤: P<0.05 compared with two-week NPC2.