Development of autoimmune diabetes in NOD mice with myeloid- specific MyD88 or TRIF deficiency.

<p>(A and C) Graphs depicting the incidence of diabetes in mice with the indicated genotypes. (B and D) Representative images and quantification of H&E stained paraffin sections of pancreatic tissue from 10-week-old mice with the indicated genotypes. Graph depicts the percentage of mice with a given histology score per genotype: 0 or I, no islet infiltrates or only small peri-islet infiltrates; II, invasive insulitis (<50% of islet area); III, severe invasive insulitis (>50% of islet area). 20–30 islets per mouse were counted. NOD.MyD88^CD11c-KO (n = 8), NOD.MyD88^LysM-KO (n = 9), NOD.TRIF^CD11c-KO (n = 7) and NOD.TRIF^LysM-KO (n = 9), <i>NOD</i>.<i>Myd88</i>^FL (n = 13), and <i>NOD</i>.<i>Trif</i>^FL (n = 12).