SDF-1α-PPADT nanoparticles promote the repair of electrical burn vascular injury in rats.

<p>(A) Hematoxylin and eosin staining of muscle and vascular tissues. Vascular morphology of the 6 s electrical burn group injected with SDF-1α-PPADT nanoparticles is relatively intact. Endothelial cells are better organized and continuous (arrow). In the group treated with only electrical burn and the group injected with SDF-1α, the inner vascular layer formed protrusions into the lumen (arrow). Images on the first rows, 200 × magnification. Images on the second rows, 400 × magnification. (B) CD31 immunohistochemical staining of muscle and vascular tissues. CD31 staining is brown and nucleus staining is blue. In the electrical burn group injected with SDF-1α-PPADT nanoparticles, more CD31+ blood vessels are present, and the lumens are round or oval (arrow). In the group treated with only electrical burn and the group injected with SDF-1α, the inner layer of the blood vessel is detached and the lumens are occluded (arrow). Images on the first rows, 200 × magnification. Images on the second rows, 400 × magnification.