Prospective evaluation of respiratory exacerbations in children with cystic fibrosis from newborn screening to 5 years of age
- Byrnes, Catherine Ann
- Vidmar, Suzanna
- Cheney, Joyce L.
- Carlin, John B.
- Armstrong, David S.
- Cooper, Peter J.
- Grimwood, Keith
- Moodie, Marj
- Robertson, Colin F.
- Rosenfeld, Margaret
- Tiddens, Harm A.
- Wainwright, Claire E.
DOIAbstract
Background Newborn screening allows novel treatments for cystic fibrosis (CF) to be trialled in early childhood before irreversible lung injury occurs. As respiratory exacerbations are a potential trial outcome variable, we determined their rate, duration and clinical features in preschool children with CF; and whether they were associated with growth, lung structure and function at age 5 years
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