Deprivation of oxygen and glucose is the main cause of neuronal cell death during cerebral infarction and can result in severe morbidity and mortality. In general, the neuroprotective therapies that are applied after ischemic stroke have been unsuccessful, despite many investigations. Acetyl-L-carnitine (ALCAR) plays an important role in mitochondrial metabolism and in modulating the coenzyme A (CoA)/acyl-CoA ratio. We investigated the protective effects of ALCAR against oxygen-glucose deprivation (OGD) in neural stem cells (NSCs). We measured cell viability, proliferation, apoptosis, and intracellular signaling protein levels after treatment with varying concentrations of ALCAR under OGD for 8 h. ALCAR protected NSCs against OGD by reducin...
Acetyl-L-carnitine (ALC), the acetyl ester of L-carnitine, is a naturally occurring substance that w...
Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaThe prese...
The present study investigated whether propionyl-L-carnitine (PLC) has neuroprotective effects, simi...
Deprivation of oxygen and glucose is the main cause of neuronal cell death during cerebral infarctio...
Deprivation of oxygen and glucose is the main cause of neuronal cell death during cerebral infarctio...
The neuronal death after ischemia is closely linked to the essential role of mitochondrial metabolis...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive regr...
Mitochondrial dysfunction is involved in a number of chronic neurodegenerative disorders. Acetyl-L-...
It is widely known that a number of chronic neurodegenerative disorders are related with dysfunctio...
Acetyl–L-carnitine (ALC) has beneficial effects in neurodegenerative diseases and was shown to be p...
P>In this work we report that carnitines, in particular acetyl-l-carnitine (ALC), are able to prolon...
Introduction: Acetyl-L-Carnitine (ALC) has been proposed to have beneficial effects in chronic neur...
Mitochondrial dysfunction characterized by depolarization of mitochondrial membranes and the initiat...
Introduction: Acetyl-L-Carnitine (ALC), a natural occurring compound in all mammalian species, play...
Mitochondrial dysfunction characterized by depolarization of mitochondrial membranes and the initiat...
Acetyl-L-carnitine (ALC), the acetyl ester of L-carnitine, is a naturally occurring substance that w...
Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaThe prese...
The present study investigated whether propionyl-L-carnitine (PLC) has neuroprotective effects, simi...
Deprivation of oxygen and glucose is the main cause of neuronal cell death during cerebral infarctio...
Deprivation of oxygen and glucose is the main cause of neuronal cell death during cerebral infarctio...
The neuronal death after ischemia is closely linked to the essential role of mitochondrial metabolis...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive regr...
Mitochondrial dysfunction is involved in a number of chronic neurodegenerative disorders. Acetyl-L-...
It is widely known that a number of chronic neurodegenerative disorders are related with dysfunctio...
Acetyl–L-carnitine (ALC) has beneficial effects in neurodegenerative diseases and was shown to be p...
P>In this work we report that carnitines, in particular acetyl-l-carnitine (ALC), are able to prolon...
Introduction: Acetyl-L-Carnitine (ALC) has been proposed to have beneficial effects in chronic neur...
Mitochondrial dysfunction characterized by depolarization of mitochondrial membranes and the initiat...
Introduction: Acetyl-L-Carnitine (ALC), a natural occurring compound in all mammalian species, play...
Mitochondrial dysfunction characterized by depolarization of mitochondrial membranes and the initiat...
Acetyl-L-carnitine (ALC), the acetyl ester of L-carnitine, is a naturally occurring substance that w...
Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaThe prese...
The present study investigated whether propionyl-L-carnitine (PLC) has neuroprotective effects, simi...