A surface based approach for cortical thickness comparison between PiB plus and PiB- Healthy Control subjects

beta-amyloid has been shown to play a crucial role in Alzheimer's disease (AD). In vivo beta-amyloid imaging using [11C]Pittsburgh compound. (PiB) positron emission tomography has made it possible to analyze the relationship between beta-amyloid deposition and different pathological markers involved in AD. PiB allows us to stratify the population between subjects which are likely to have prodromal AD, and those who don't. The comparison of the cortical thickness in these different groups is important to better understanding and detect the first symptoms of the disease which may lead to an earlier therapeutic care to reduce neurone loss