Abyssomicins from the South China Sea deep-sea sediment Verrucosispora sp.: natural thioether michael addition adducts as antitubercular prodrugs
- Wang, Qian
- Song, Fuhang
- Xiao, Xue
- Huang, Pei
- Li, Li
- Monte, Aaron
- Abdel-Mageed, Wael M.
- Wang, Jian
- Guo, Hui
- He, Wenni
- Xie, Feng
- Dai, Huanqin
- Liu, Miaomiao
- Chen, Caixia
- Xu, Hao
- Liu, Mei
- Piggott, Andrew M.
- Liu, Xueting
- Capon, Robert J.
- Zhang, Lixin
DOIAbstract
From the deep: The title actinomycete yielded three new abyssomicins J-L. The dimeric thioether J (see scheme) represents a unique example of a masked Michael acceptor with anti-TB properties. Mechanistic insights into the biosynthesis, biomimetic synthesis, stability, and biological mechanism of action of abyssomicins aid our understanding of, and prospects for the development of Michael-acceptor-based drugs. Copyrigh
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