ASAP ECMO: antibiotic, sedative and analgesic pharmacokinetics during extracorporeal membrane oxygenation: a multi-centre study to optimise drug therapy during ECMO
- Shekar, Kiran
- Roberts, Jason A.
- Welsh, Susan
- Buscher, Hergen
- Rudham, Sam
- Burrows, Fay
- Ghassabian, Sussan
- Wallis, Steven C.
- Levkovich, Bianca
- Pellegrino, Vin
- McGuiness, Shay
- Parke, Rachael
- Gilder, Eileen
- Barnett, Adrian G.
- Walsham, James
- Mullany, Daniel V.
- Fung, Yoke L.
- Smith, Maree T.
- Fraser, John F.
Publication date
November 2012
DOI Publisher
Springer Science and Business Media LLC ISSN
1471-2253 Citation count (estimate)
46Abstract
Background: Given the expanding scope of extracorporeal membrane oxygenation (ECMO) and its variable impact on drug pharmacokinetics as observed in neonatal studies, it is imperative that the effects of the device on the drugs commonly prescribed in the intensive care unit (ICU) are further investigated. Currently, there are no data to confirm the appropriateness of standard drug dosing in adult patients on ECMO. Ineffective drug regimens in these critically ill patients can seriously worsen patient outcomes. This study was designed to describe the pharmacokinetics of the commonly used antibiotic, analgesic and sedative drugs in adult patients receiving ECMO
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