Association of FOXE1 polyalanine repeat region with papillary thyroid cancer
- Bullock, Martyn
- Duncan, Emma L.
- O'Neill, Christine
- Tacon, Lyndal
- Sywak, Mark
- Sidhu, Stan
- Delbridge, Leigh
- Learoyd, Diana
- Robinson, Bruce G.
- Ludgate, Marian
- Clifton-Bligh, Roderick J.
Publication date
September 2012
DOI Publisher
The Endocrine Society ISSN
0021-972X Citation count (estimate)
36Abstract
Context: Polyalanine tract variations in transcription factors have been identified for a wide spectrum of developmental disorders. The thyroid transcription factor forkhead factor E1 (FOXE1) contains a polymorphic polyalanine tract with 12-22 alanines. Single-nucleotide polymorphisms (SNP) close to this locus are associated with papillary thyroid cancer (PTC), and a strong linkage disequilibrium block extends across this region
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