Tissues damaging effect of zinc oxide nanoparticle on Oreochromis mossambicus

Certain elements behave differently when their particle size reduced to nano-level and it exerts different impact on the exposed organisms. Such an impact particularly of toxicological could be evaluated through animal models. Then only safe materials can be suggested for various applications including pharmaceuticals. Subsequently creat awareness among the public about its ill effect from the environment. The effect of oral exposure of ZnO mamp[artoc;es (50-100mm) at different concentrations (70 ppm, 80ppm, 90ppm and 100ppm) on O. mossambicus at 12 day duriation was evaluated. In this regard the biochemical analysis on every 3 days interval. The tissue damaging effects caused in the ZnO nanoparticle exposed fish was evident from the liver and gill enzyme assays. The tissue damaging level as discernible fro the biomarker enzymes modulations in glutamate oxaloacetic transaminase (GOT), glutamate pyruvic transaminase (GPT) and alkaline phosphatase (ALP). All these enzyme level significantly increases with increasing does at early stages, subsequently a gradual decrease of both ALP and GOT was noted despite increased level of GOT. GOT has been found much more active than GPT, Enzyme activities are based on the formation of oxaloacetate (GOT) or pyruvate (GPT) from aspartic acid and alanine respectively wit oxoglutarate. A linear relationship was observed between the enzyme concentration and activity of GOT and GPT, however, GOT showed a maximum activity than GPT