Patient samples of renal cell carcinoma show reduced expression of TRAF1 compared with normal kidney and functional studies in vitro indicate TRAF1 promotes apoptosis: Potential for targeted therapy
- Rajandram, Retnagowri
- Bennett, Nigel C.
- Wang, Zhiqiang
- Perry-Keene, Joanna
- Vesey, David A.
- Johnson, David W.
- Gobe, Glenda C.
Publication date
August 2012
DOI Publisher
Ovid Technologies (Wolters Kluwer Health) ISSN
0031-3025Abstract
Aims: The tumour necrosis factor (TNF) receptor-associated factor (TRAF) family of proteins links the TNF receptor superfamily to cell signalling cascades. TRAF1 is involved in regulation of apoptosis, proliferation, differentiation and stress responses. It has a role in development of several malignancies, but no information for renal cell carcinoma (RCC) is available
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