The relation between steady-state plasma ethosuximide level and drug dose was studied in 46 patients. In this population, plasma drug levels were proportional to drug dose, expressed on a body weight basis. Age did not alter this relationship, but plasma levels increased more rapidly, relative to dose, in females than in males. Intake of methylphenobarbitone, but not intake of certain other anticonvulsants (phenytoin, phenobarbitone, primidone and carbamazepine) altered the relationship between plasma ethosuximide level and ethosuximide dose. In individual patients, successive dose increments of equal size produced progressively greater increases in steady-state plasma ethosuximide levels. This phenomenon has obvious therapeutic implication...
Although combination therapy with the oral fluoropyrimidine anticancer drug S-1 and the anticonvulsa...
A multi-center survey of antiepileptic treatment was conducted in Italy on 245 previously untreated ...
Simultaneous steady-state plasma concentrations of carbamazepine and carbamazepine-10,11-epoxide hav...
Abstract 1. To assess the effect of enzyme inducing anticonvulsants on ethosuximide pharmacokinetic...
The plasma levels of various anticonvulsant drugs provide a measure of their concentration in the br...
The plasma concentrations of anticonvulsant drugs, and of certain of their biologically active metab...
Rates for being free of all epileptic seizures for at least 1 year and for ceasing therapy after 3–5...
The influence of dosage, age, and co-medication on plasma topiramate (TPM) concentrations at steady ...
The effects of age, dosage, and type of comedication on plasma lamotrigine (LTG) concentrations and ...
SUMMARY Etoraidate was injected i.v. within 10 or 60s at various doses. After etonudate 0.3 nig kg t...
We describe a case of fatal overdosage with primidone and methsuximide. During the early phase of th...
Aims: To provide a brief critical review of the basis and contemporary practice of monitoring the co...
Aims: To provide a brief critical review of the basis and contemporary practice of monitoring the co...
As antiepileptic drugs (AEDs) and psychotropic agents are increasingly used in combination, the poss...
Anti-epileptic drugs frequently interact due to pharmacokinetic features (induction or inhibition of...
Although combination therapy with the oral fluoropyrimidine anticancer drug S-1 and the anticonvulsa...
A multi-center survey of antiepileptic treatment was conducted in Italy on 245 previously untreated ...
Simultaneous steady-state plasma concentrations of carbamazepine and carbamazepine-10,11-epoxide hav...
Abstract 1. To assess the effect of enzyme inducing anticonvulsants on ethosuximide pharmacokinetic...
The plasma levels of various anticonvulsant drugs provide a measure of their concentration in the br...
The plasma concentrations of anticonvulsant drugs, and of certain of their biologically active metab...
Rates for being free of all epileptic seizures for at least 1 year and for ceasing therapy after 3–5...
The influence of dosage, age, and co-medication on plasma topiramate (TPM) concentrations at steady ...
The effects of age, dosage, and type of comedication on plasma lamotrigine (LTG) concentrations and ...
SUMMARY Etoraidate was injected i.v. within 10 or 60s at various doses. After etonudate 0.3 nig kg t...
We describe a case of fatal overdosage with primidone and methsuximide. During the early phase of th...
Aims: To provide a brief critical review of the basis and contemporary practice of monitoring the co...
Aims: To provide a brief critical review of the basis and contemporary practice of monitoring the co...
As antiepileptic drugs (AEDs) and psychotropic agents are increasingly used in combination, the poss...
Anti-epileptic drugs frequently interact due to pharmacokinetic features (induction or inhibition of...
Although combination therapy with the oral fluoropyrimidine anticancer drug S-1 and the anticonvulsa...
A multi-center survey of antiepileptic treatment was conducted in Italy on 245 previously untreated ...
Simultaneous steady-state plasma concentrations of carbamazepine and carbamazepine-10,11-epoxide hav...