The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria
- Skinner-Adams, Tina S.
- Peatey, Christopher L.
- Anderson, Karen
- Trenholme, Katharine R.
- Krige, David
- Brown, Christopher L.
- Stack, Colin
- Nsangou, Desire M. M.
- Mathews, Rency T.
- Thivierge, Karine
- Dalton, John P.
- Gardinerd, Donald L.
Publication date
June 2012
DOI Publisher
American Society for Microbiology ISSN
0066-4804 Citation count (estimate)
18Abstract
Malaria remains a significant risk in many areas of the world, with resistance to the current antimalarial pharmacopeia an everincreasing problem. The M1 alanine aminopeptidase (PfM1AAP) and M17 leucine aminopeptidase (PfM17LAP) are believed to play a role in the terminal stages of digestion of host hemoglobin and thereby generate a pool of free amino acids that are essential for parasite growth and development. Here, we show that an orally bioavailable aminopeptidase inhibitor, CHR-2863, is efficacious against murine malaria
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