The facile surface chemical modification of a single glass nanopore and its use in the nonenzymatic detection of uric acid

A conical glass nanopore was first modified with ultrathin gold nanofilm via a simple and innovative chemical reduction of HAuCl4 on a surface-attached poly(L-histidine) monolayer in the presence of a mild reductant, NH2OH center dot HCl, followed by surface functionalization with 2-thiouracil, and exploited for the selective nonenzymatic detection of uric acid and especially for serum sample detection