Two-dimensional hybrid mesoporous Fe2O3-graphene nanostructures: A highly active and reusable peroxidase mimetic toward rapid, highly sensitive optical detection of glucose

In this article, for the first time, two-dimensional hybrid mesoporous Fe2O3-graphene (mFe(2)O(3)-G) nanostructures were developed as a peroxidase mimetic with catalytic activities superior to those of mFe(2)O(3), G, and previously reported Fe-based peroxidase mimetics. The high-surface-area mFe(2)O(3) not only offers a large number of catalytically active sites, but also facilitates the diffusion of 3,3,5,5-tetramethylbenzidine (TMB) and H2O2 toward G surface. On the other hand, G is pi-rich and thus favors the adsorption and enrichment of TMB within these pores. These synergistic effects lead to highly improved catalytic performances. Based on these findings, a simple, rapid, and highly sensitive and selective optical detector of glucose has been developed and demonstrated in buffer solution with a pretty low detection limit of 0.5 mu M. In addition, this nanosensor is reusable and can also be used for glucose detection in diluted serum. (C) 2013 Elsevier B.V. All rights reserved