An improved sensitivity nonenzymatic glucose biosensor based on a CU(x)O modified electrode

An enzymeless biosensor based on Cu(x)O/Cu electrode was investigated in this study. The XRD analysis confirmed that Cu(x)O nanostructured material was composed of Cu(2)O and CuO. The FESEM images showed that the catalysts were flower-like with large surface area. From cyclic voltammograms, the peak current of Cu(x)O/Cu electrode was 6, 6.3 and 1.7 times higher than that of the Cu foil, Cu(2)O/GCE and CuO/GCE electrodes, respectively. The biosensor based on Cu(x)O/Cu exhibited excellent performance for glucose detection, giving a linear dependence between current and glucose concentration (R = 0.996), with a low detection limit (0.049 mM) and high sensitivity (1.62 mA cm(-2) mM(-1)). Finally, the Cu(x)O/Cu sensor was applied and checked in the glucose determination in blood serum samples. (C) 2010 Elsevier B.V. All rights reserved