Vilsmeier Reaction of Enaminones: Efficient Synthesis of Halogenated Pyridin-2(1H)-ones

  • Zhang R
  • Zhang DY
  • Guo YL
  • Zhou GY
  • Jiang ZJ
  • Dong DW
Publication date
January 2008
ISSN
0022-3263
Citation count (estimate)
39

Abstract

A facile and efficient one-pot synthesis of halogenated pyridin-2(1H)-ones from a series of readily available enaminones under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation, and intramolecular nucleophilic cyclization is proposed

Extracted data

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