Differential genomic DNA methylation has the potential to influence the development of T cell. cytokine production profiles. Therefore, we have conducted a clonal analysis of interferon (IFN)-gamma and interleukin (IL)-3 gene methylation and messenger (m)RNA expression in primary CD8(+) T cells during the early stages of activation, growth, and cytokine expression. Despite similar distributions and densities of CpG methylation sites, the IFN-gamma and IL-3 promoters exhibited differential demethylation in the same T cell clone, and heterogeneity between clones. Methylation patterns and mRNA levels were correlated for both genes, but demethylation of the IFN-gamma promoter was widespread across >300 basepairs in clones expressing high levels...
The immune system can respond to various types of pathogens such as bacteria, viruses, tumors and pa...
<p>(<b>A</b>) Gene map of the methylated IFNG promoter in CD4<sup>+</sup> T cells cultured without S...
DNA demethylation has been found to occur at the promoters of a number of actively expressed cytokin...
Differential genomic DNA methylation has the potential to influence the development of T cell cytoki...
Interferon-gamma (IFN gamma) gene expression is tightly regulated in early life, and exaggerated neg...
Interferon gamma (IFNγ) supports effector responses of CD8+ cytotoxic T lymphocytes (CTLs) and is a ...
Interferon- (IFN-) γ is an essential cytokine for immunity against intracellular pathogens and cance...
Cytokine memory for IFN-{gamma} production by effector/memory Th1 cells plays a key role in both pro...
Interferon gamma (IFNγ) supports effector responses of CD8+ cytotoxic T lymphocytes (CTLs) and is a ...
Interferon gamma (IFNγ) supports effector responses of CD8+ cytotoxic T lymphocytes (CTLs) and is a ...
IFN- is a potent pleiotropic Th1 cytokine, the production of which is tightly regulated during fetal...
Cytokine secretion profiles of activated T cells are critical for maintaining the immunologic balanc...
textabstractImmunosuppressive drug therapy is required to treat patients with autoimmune disease and...
Interferon- (IFN) gene expression is tightly regulated in early life, and exaggerated negative contr...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2006.In title on t.p., "[g...
The immune system can respond to various types of pathogens such as bacteria, viruses, tumors and pa...
<p>(<b>A</b>) Gene map of the methylated IFNG promoter in CD4<sup>+</sup> T cells cultured without S...
DNA demethylation has been found to occur at the promoters of a number of actively expressed cytokin...
Differential genomic DNA methylation has the potential to influence the development of T cell cytoki...
Interferon-gamma (IFN gamma) gene expression is tightly regulated in early life, and exaggerated neg...
Interferon gamma (IFNγ) supports effector responses of CD8+ cytotoxic T lymphocytes (CTLs) and is a ...
Interferon- (IFN-) γ is an essential cytokine for immunity against intracellular pathogens and cance...
Cytokine memory for IFN-{gamma} production by effector/memory Th1 cells plays a key role in both pro...
Interferon gamma (IFNγ) supports effector responses of CD8+ cytotoxic T lymphocytes (CTLs) and is a ...
Interferon gamma (IFNγ) supports effector responses of CD8+ cytotoxic T lymphocytes (CTLs) and is a ...
IFN- is a potent pleiotropic Th1 cytokine, the production of which is tightly regulated during fetal...
Cytokine secretion profiles of activated T cells are critical for maintaining the immunologic balanc...
textabstractImmunosuppressive drug therapy is required to treat patients with autoimmune disease and...
Interferon- (IFN) gene expression is tightly regulated in early life, and exaggerated negative contr...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2006.In title on t.p., "[g...
The immune system can respond to various types of pathogens such as bacteria, viruses, tumors and pa...
<p>(<b>A</b>) Gene map of the methylated IFNG promoter in CD4<sup>+</sup> T cells cultured without S...
DNA demethylation has been found to occur at the promoters of a number of actively expressed cytokin...