Mobilization of stem cells with pegylated granulocyte colony-stimulating factor (peg-G-CSF) modulates donor T- and natural killer T-cell (NKT-cell) functions, thus separating graft-versus-host from graft-versus-leukemia disease in animal models. We report a phase I/II study that analyzed the feasibility of mobilizing stem cells from normal donors with peg-G-CSF and the ability of these cells to restore hematopoiesis in allogeneic transplant recipients after myeloablative conditioning. Administration of 6 mg of peg-G-CSF resulted in suboptimal stem cell mobilization, with a peak peripheral blood CD34(+) count of 29 +/- 5/mu L. Apheresis 4 days after peg-G-CSF yielded 2.7 +/-.4 x 10(6) CD34(+) cells/kg recipient weight, and all donors require...
The mobilization of stem cells from bone marrow to peripheral blood in can-cer patients administered...
The mobilization of stem cells from bone marrow to peripheral blood in can-cer patients administered...
In vivo induction of T-cell hyporesponsiveness and alteration of immunological cells of bone marrow ...
AbstractMobilization of stem cells with pegylated granulocyte colony-stimulating factor (peg-G-CSF) ...
The separation of graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) remains the "holy...
Peripheral blood stem cells (PBSCs), usually mobilized with granulocyte colony-stimulating factor (G...
Donor treatment with granulocyle-colony stimulating factor (G-CSF) is known to modulate immune funct...
The objective was to observe the effect of G-CSF as a mobilizer of hematopoitic stem cells on the ab...
AbstractGranulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating ...
BackgroundAllogeneic hematopoietic stem cell transplantation is associated with a high risk of immun...
The separation of graft-versus-host dis-ease (GVHD) and graft-versus-leukemia (GVL) remains the “hol...
AbstractGranulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating ...
We investigated whether the protection from graft-versus-host disease (GVHD) afforded by donor treat...
Background: Allogeneic hematopoietic stem cell transplantation is associated with a high risk of imm...
Minimization of graft-versus-host disease (GVHD) with preservation of the graft-versus-leukemia (GVL...
The mobilization of stem cells from bone marrow to peripheral blood in can-cer patients administered...
The mobilization of stem cells from bone marrow to peripheral blood in can-cer patients administered...
In vivo induction of T-cell hyporesponsiveness and alteration of immunological cells of bone marrow ...
AbstractMobilization of stem cells with pegylated granulocyte colony-stimulating factor (peg-G-CSF) ...
The separation of graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) remains the "holy...
Peripheral blood stem cells (PBSCs), usually mobilized with granulocyte colony-stimulating factor (G...
Donor treatment with granulocyle-colony stimulating factor (G-CSF) is known to modulate immune funct...
The objective was to observe the effect of G-CSF as a mobilizer of hematopoitic stem cells on the ab...
AbstractGranulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating ...
BackgroundAllogeneic hematopoietic stem cell transplantation is associated with a high risk of immun...
The separation of graft-versus-host dis-ease (GVHD) and graft-versus-leukemia (GVL) remains the “hol...
AbstractGranulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating ...
We investigated whether the protection from graft-versus-host disease (GVHD) afforded by donor treat...
Background: Allogeneic hematopoietic stem cell transplantation is associated with a high risk of imm...
Minimization of graft-versus-host disease (GVHD) with preservation of the graft-versus-leukemia (GVL...
The mobilization of stem cells from bone marrow to peripheral blood in can-cer patients administered...
The mobilization of stem cells from bone marrow to peripheral blood in can-cer patients administered...
In vivo induction of T-cell hyporesponsiveness and alteration of immunological cells of bone marrow ...