Spontaneous ventilation after induction of anaesthesia with intravenous alfaxalone or propofol was evaluated in a dose escalation study using 6 dogs. Each dog was dosed at 1×, 2×, 5×, 10× and 20× multiples of the labelled doses (2mg/kg for alfaxalone; 6.5mg/kg for propofol), until apnoea was observed. For each administration, the entire calculated dose was delivered over 1 min. All 6 dogs ventilated spontaneously after labelled (1×) doses of each drug but became apnoeic at 5× dose of propofol versus 20× dose of alfaxalone. For propofol at 2× and 5× doses, 4 and 0 dogs ventilated spontaneously respectively. For alfaxalone at 2×, 5× and 10× doses all 6, 4 and 1 dog ventilated spontaneously, respectively. The median dose which induced apnoea w...
The pharmacological effects of intramuscular (IM) administration of alfaxalone combined with medetom...
Objective: To compare the effects of propofol and alfaxalone on respiration in cats. Study design: ...
Objectives The aim of the study was to evaluate, in a controlled, randomised, masked clinical trial,...
© 2018 Sarah Elizabeth BigbyAnimals are often given combinations of drugs that produce sedation prio...
Objective: To evaluate quality of anaesthetic induction and cardiorespiratory effects following rapi...
Objective: To qualitatively assess the co-induction of anaesthesia with midazolam and alfaxalone an...
Objective Propofol may cause adverse effects (e.g. apnoea, hypotension) at induction of anaesthesia...
To systematically review the quality of evidence comparing the cardiopulmonary effects and quality o...
The pharmacological effects of the anesthetic alfaxalone were evaluated after intramuscular (IM) adm...
To compare the anesthetic effects after intravenous administration of alfaxalone or propofol without...
We aimed to evaluate the induction, anesthesia, and cardiorespiratory effects of intramuscular (IM) ...
To systematically review the quality of evidence comparing the cardiopulmonary effects and quality o...
Thirty-nine healthy cats that were presented for ovariohysterectomy received intramuscular acepromaz...
OBJECTIVE: The effects of lidocaine, administered before induction of anaesthesia with propofol, on ...
We describe the clinical signs and management of a case of anaphylaxis in a dog after intravenous ad...
The pharmacological effects of intramuscular (IM) administration of alfaxalone combined with medetom...
Objective: To compare the effects of propofol and alfaxalone on respiration in cats. Study design: ...
Objectives The aim of the study was to evaluate, in a controlled, randomised, masked clinical trial,...
© 2018 Sarah Elizabeth BigbyAnimals are often given combinations of drugs that produce sedation prio...
Objective: To evaluate quality of anaesthetic induction and cardiorespiratory effects following rapi...
Objective: To qualitatively assess the co-induction of anaesthesia with midazolam and alfaxalone an...
Objective Propofol may cause adverse effects (e.g. apnoea, hypotension) at induction of anaesthesia...
To systematically review the quality of evidence comparing the cardiopulmonary effects and quality o...
The pharmacological effects of the anesthetic alfaxalone were evaluated after intramuscular (IM) adm...
To compare the anesthetic effects after intravenous administration of alfaxalone or propofol without...
We aimed to evaluate the induction, anesthesia, and cardiorespiratory effects of intramuscular (IM) ...
To systematically review the quality of evidence comparing the cardiopulmonary effects and quality o...
Thirty-nine healthy cats that were presented for ovariohysterectomy received intramuscular acepromaz...
OBJECTIVE: The effects of lidocaine, administered before induction of anaesthesia with propofol, on ...
We describe the clinical signs and management of a case of anaphylaxis in a dog after intravenous ad...
The pharmacological effects of intramuscular (IM) administration of alfaxalone combined with medetom...
Objective: To compare the effects of propofol and alfaxalone on respiration in cats. Study design: ...
Objectives The aim of the study was to evaluate, in a controlled, randomised, masked clinical trial,...