The androgen receptor CAG repeat polymorphism and modification of breast cancer risk in BRCA1 and BRCA2 mutation carriers
- Spurdle, Amanda B.
- Antoniou, Antonis C.
- Duffy, David L.
- Pandeya, Nirmala
- Kelemen, Livia
- Chen, Xiaoqing
- Peock, Susan
- Cook, Margaret R.
- Smith, Paula L.
- Purdie, David M.
- Newman, Beth
- Dite, Gillian S.
- Apicella, Carmel
- Southey, Melissa C.
- Giles, Graham G.
- Hopper, John L.
- kConFaB
- EMBRACE Study Collaborators
- ABCFS
- AJBCS
- Chenevix-Trench, Georgia
- Easton, Douglas F.
DOIAbstract
Introduction The androgen receptor (AR) gene exon 1 CAG repeat polymorphism encodes a string of 9-32 glutamines. Women with germline BRCA1 mutations who carry at least one AR allele with 28 or more repeats have been reported to have an earlier age at onset of breast cancer
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