Genes and gene ontologies common to airflow obstruction and emphysema in the lungs of patients with COPD
- Savarimuthu Francis, Santiyagu M.
- Larsen, Jill E.
- Pavey, Sandra J.
- Duhig, Edwina E.
- Clarke, Belinda E.
- Bowman, Rayleen V.
- Hayward, Nick K.
- Fong, Kwun M.
- Yang, Ian A.
Publication date
March 2011
DOI Publisher
Public Library of Science (PLoS) ISSN
1932-6203 Citation count (estimate)
16Abstract
Chronic obstructive pulmonary disease (COPD) is a major public health problem with increasing prevalence worldwide. The primary aim of this study was to identify genes and gene ontologies associated with COPD severity. Gene expression profiling was performed on total RNA extracted from lung tissue of 18 former smokers with COPD. Class comparison analysis on mild (n = 9, FEV(1) 80-110% predicted) and moderate (n = 9, FEV(1) 50-60% predicted) COPD patients identified 46 differentially expressed genes (
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