Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. Here we report the identification of three variants in the RUNX3, LTBR-TNFRSF1A and IL12B regions convincingly associated with ankylosing spondylitis (P < 5 x 10(-8) in the combined discovery and replication datasets) and a further four loci at PTGER4, TBKBP1, ANTXR2 and CARD9 that show strong association across all our datasets (P < 5 x 10(-6) overall, with support in each of the three datasets studied). We also show that polymorphisms of ERAP1, which encodes an endoplasmic reticulum aminopeptidase involved in peptide trimming before HLA class I presentation, ...
Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B*27...
Objective. HLA-B27 and ERAP1 are the two strongest predisposing genetic factors to Ankylosing Spondy...
The association of endoplasmic reticulum aminopeptidase (ERAP2) with ankylosing spondylitis (AS) was...
Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting the spine ...
Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting the spine ...
For more than 40 y, expression of HLA-B27 has been strongly associated with the chronic inflammatory...
The endoplasmic reticulum aminopeptidase 1 (ERAP1) performs a major role in antigen processing, trim...
Ankylosing Spondylitis (AS) is a chronic inflammatory disease which commonly affects the spine occur...
Ankylosing spondylitis (AS) is associated with HLA-B*2704 and B*2705 but not with HLA-B*2706 and B*2...
The strong genetic association of ERAP1 (endoplasmic reticulum aminopeptidase 1) with ankylosing spo...
The mechanism by which human leukocyte antigen B27 (HLA-B27) contributes to ankylosing spondylitis (...
Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B*27...
Objective. HLA-B27 and ERAP1 are the two strongest predisposing genetic factors to Ankylosing Spondy...
The association of endoplasmic reticulum aminopeptidase (ERAP2) with ankylosing spondylitis (AS) was...
Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting the spine ...
Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting the spine ...
For more than 40 y, expression of HLA-B27 has been strongly associated with the chronic inflammatory...
The endoplasmic reticulum aminopeptidase 1 (ERAP1) performs a major role in antigen processing, trim...
Ankylosing Spondylitis (AS) is a chronic inflammatory disease which commonly affects the spine occur...
Ankylosing spondylitis (AS) is associated with HLA-B*2704 and B*2705 but not with HLA-B*2706 and B*2...
The strong genetic association of ERAP1 (endoplasmic reticulum aminopeptidase 1) with ankylosing spo...
The mechanism by which human leukocyte antigen B27 (HLA-B27) contributes to ankylosing spondylitis (...
Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B*27...
Objective. HLA-B27 and ERAP1 are the two strongest predisposing genetic factors to Ankylosing Spondy...
The association of endoplasmic reticulum aminopeptidase (ERAP2) with ankylosing spondylitis (AS) was...