CD8+ T-cell expansions are the primary manifestation of T-cell large granular lymphocytic leukemia (T-LGLL), which is frequently accompanied by neutropenia and rheumatoid arthritis, and also occur as a secondary phenomenon in leukemia patients treated with dasatinib, notably in association with various drug-induced side-effects. However, the mechanisms that underlie the genesis and maintenance of expanded CD8+ T-cell receptor (TCR)-Vβ+ populations in these patient groups have yet to be fully defined. In this study, we performed a comprehensive phenotypic and clonotypic assessment of expanded (TCR-Vβ+) and residual (TCR-Vβ−) CD8+ T-cell populations in T-LGLL and dasatinib-treated chronic myelogenous leukemia (CML) patients. The dominant CD8+...
Am J Pathol. 2001 Nov;159(5):1861-8. Immunophenotypic analysis of the TCR-Vbeta repertoire in 98 ...
Large granular lymphocyte leukemia (LGLL) is characterized by somatic gain-of-function STAT3 mutatio...
We demonstrated in previous studies that interleukin (IL) -2 supports in vitro cell proliferation of...
CD8+ T-cell expansions are the primary manifestation of T-cell large granular lymphocytic leukemia (...
CD8(+) T-cell expansions are the primary manifestation of T-cell large granular lymphocytic leukemia...
Clonal CD8 +/T-cell receptor (TCR)αβ+ T-cell large granular lymphocyte (T-LGL) proliferations consti...
The tyrosine kinase inhibitor dasatinib exerts immunosuppressive effects on T-cells and NK-cells in ...
The tyrosine kinase inhibitor dasatinib exerts immunosuppressive effects on T-cells and NK-cells in ...
T cell large granular lymphocytic leukemia (T-LGLL) is a rare lymphoproliferative disorder of mature...
AbstractA higher chronic expansion of effector cytotoxic CD8+DR+ T-lymphocytes has been reported in ...
CD4+ T-cell large granular lymphocyte leukemia (T-LGLL) is a rare subtype of T-LGLL with unknown eti...
STAT3 mutations have been described in 30-40% of T-large granular lymphocyte (T-LGL) leukemia patien...
CD8+ T cell immunosurveillance is crucial in solid tumors and T cell dysfunction leads to tumor prog...
TCRγδ+ T-LGL leukemia is a rare form of chronic mature T cell disorders in elderly, which is general...
Am J Pathol. 2001 Nov;159(5):1861-8. Immunophenotypic analysis of the TCR-Vbeta repertoire in 98 ...
Large granular lymphocyte leukemia (LGLL) is characterized by somatic gain-of-function STAT3 mutatio...
We demonstrated in previous studies that interleukin (IL) -2 supports in vitro cell proliferation of...
CD8+ T-cell expansions are the primary manifestation of T-cell large granular lymphocytic leukemia (...
CD8(+) T-cell expansions are the primary manifestation of T-cell large granular lymphocytic leukemia...
Clonal CD8 +/T-cell receptor (TCR)αβ+ T-cell large granular lymphocyte (T-LGL) proliferations consti...
The tyrosine kinase inhibitor dasatinib exerts immunosuppressive effects on T-cells and NK-cells in ...
The tyrosine kinase inhibitor dasatinib exerts immunosuppressive effects on T-cells and NK-cells in ...
T cell large granular lymphocytic leukemia (T-LGLL) is a rare lymphoproliferative disorder of mature...
AbstractA higher chronic expansion of effector cytotoxic CD8+DR+ T-lymphocytes has been reported in ...
CD4+ T-cell large granular lymphocyte leukemia (T-LGLL) is a rare subtype of T-LGLL with unknown eti...
STAT3 mutations have been described in 30-40% of T-large granular lymphocyte (T-LGL) leukemia patien...
CD8+ T cell immunosurveillance is crucial in solid tumors and T cell dysfunction leads to tumor prog...
TCRγδ+ T-LGL leukemia is a rare form of chronic mature T cell disorders in elderly, which is general...
Am J Pathol. 2001 Nov;159(5):1861-8. Immunophenotypic analysis of the TCR-Vbeta repertoire in 98 ...
Large granular lymphocyte leukemia (LGLL) is characterized by somatic gain-of-function STAT3 mutatio...
We demonstrated in previous studies that interleukin (IL) -2 supports in vitro cell proliferation of...