Myxoid synovial sarcoma: An unusual clinical and pathologic presentation

Myxoid Synovial sarcoma (SS) is a unique, uncommon, malignant variant of Synovial sarcoma with unusual clinical and pathologic presentation. Recognition of synovial sarcomas with massive myxoid feature is important because these can easily be mistaken for other myxoid soft tissue neoplasms. Here, we report a rare case of myxoid synovial sarcoma in a 28-year-old male who presented with slow growing localized tumor in the anterior aspect of his left forearm. This tumor was circumscribed and showed a well-defined capsule. The cut surface was gray, soft and myxoid. Histological examination showed proliferation of spindle cells in the predominantly myxoid stroma, including uniform spindled cells with fascicular growth patterns, collagenous stroma and hemangiopericytoma-like vascular patterns. Small areas of glandular components were also obtained after many serial sections of the tumor, with features more typical of synovial sarcoma. Our case strongly highlights that to make a correct diagnosis, clinical correlation and proper histomorphological examination along with immunohistochemical studies is essential