In the context of climate change in West Africa characterized by a reduction of precipitation, this study was conducted to evaluate the impact of climate change on water resources from now to the end of the 21st century in the transboundary watershed of the Sassandra River shared by Guinea and Côte d’Ivoire. Historical and future climate data of Representative Concentration Pathways (RCPs) 4.5 and 8.5 were projected with the Abdus Salam International Centre for Theoretical Physics (ICTP) Regional Climate Model (RegCM4). The hydrological modeling of the river basin was carried out with the conceptual hydrological model, GR2M, a monthly time steps model that allows for the assessment of the discharge of the Sassandra River for each climate sc...