Analysis of stages of labor, stress indexes and coagulation function in dexmedetomidine combined with regular discontinuous epidural injection for labor analgesia

Objective: To study the changes in stages of labor, stress indexes and coagulation function in dexmedetomidine combined with regular discontinuous epidural injection for labor analgesia. Methods: A total of 128 cases of full-term primiparas receiving epidural labor analgesia in our hospital between May 2013 and December 2015 were randomly divided into the dexmedetomidine (Dex group) and control group, the analgesia method for Dex group was dexmedetomidine combined with regular discontinuous epidural injection, and the analgesia method for control group was regular discontinuous epidural injection. The analgesic effect, time of stages of labor as well as stress indexes and coagulation function indexes in serum were evaluated. Results: The analgesic onset time and effective time of Dex group were significantly shorter than those of control group, the hold time was significantly longer than that of control group, latency time was not different from that of control group, and the time of the second stage of labor and the time of the third stage of labor were significantly shorter than those of control group; in the second and third stages of labor, blood glucose, blood cortisol, blood insulin, epinephrine and norepinephrine content of Dex group were significantly lower than those of control group; 24 h after childbirth, PT, APTT and TT of Dex group were significantly longer than those of control group, and FIB and D-D content were significantly lower than those of control group. Conclusions: Compared with epidural labor analgesia, the dexmedetomidine combined with regular discontinuous epidural injection can improve the analgesic effect, promote the progress of labor and reduce stress reaction as well as postpartum hypercoagulable state, and it is a more ideal solution for labor analgesia