ENGINEERING MATERIALS SURFACES BY MICROFABRICATION TECHNIQUES, TO REGULATE IN VITRO CELL FUNCTIONS: REVIEW

It has been clear that the surface properties of the materials used as substrates for cell culture can influence the cell behavior affecting different factors such as cell orientation, adhesion, growth, differentiation, and apoptosis. In the last few years, several micro and nanofabrication techniques have emerged as important tools used to modify the surface properties of those materials at the micro or nano scale, topologically or chemically. This paper reviews the most used microfabrication techniques to introduce modifications on the materials surfaces and its implications on cell behavior. This review ends up showing the possible medical applications derived as a source of future work in the field