In traditional Indian medicine, the crude drug Hemidesmus indicus root—commonly known as Indian sarsaparilla—is used alone or in poly-herbal preparations for the treatment of a wide range of diseases. The present study focuses on the cancer chemopreventive and therapeutic potential of H. indicus extracts on an acute lymphoblastic leukemia cell line (CCRF-CEM). With this aim in mind, we subjected H. indicus roots to two subsequent extractions (hydro-alcoholic extraction and soxhlet extraction). As DNA damage is an important prerequisite for the induction of mutations/cancer by genotoxic carcinogens, cancer chemoprevention may be achieved by preventing genotoxicity. Through an integrated experimental approach, we explored the genoprotective p...
The research of new botanicals is an important aspect of the modern research focused on prevention a...
Background: Although cancers are characterized by the deregulation of multiple signalling pathways, ...
The ability of anticancer treatments to promote the activation of tumor-reactive adaptive immune res...
In traditional Indian medicine, the crude drug Hemidesmus indicus root—commonly known as Indian sars...
Ethnopharmacological relevance: The decoction of the roots of Hemidesmus indicus is widely used in t...
Ethnopharmacological relevance: The decoction of the roots of Hemidesmus indicus is widely used in t...
Indian Sarsaparilla (Hemidesmus indicus R. Br.) is widely used in Indian traditional medicine. In th...
Indian Sarsaparilla (Hemidesmus indicus R. Br.) is widely used in Indian traditional medicine. In th...
Proteasome inhibition represents an important anticancer strategy. Here, we studied the mechanisms a...
The research of new botanicals is an important aspect of the modern research focused on prevention a...
Background: Although cancers are characterized by the deregulation of multiple signalling pathways, ...
The ability of anticancer treatments to promote the activation of tumor-reactive adaptive immune res...
In traditional Indian medicine, the crude drug Hemidesmus indicus root—commonly known as Indian sars...
Ethnopharmacological relevance: The decoction of the roots of Hemidesmus indicus is widely used in t...
Ethnopharmacological relevance: The decoction of the roots of Hemidesmus indicus is widely used in t...
Indian Sarsaparilla (Hemidesmus indicus R. Br.) is widely used in Indian traditional medicine. In th...
Indian Sarsaparilla (Hemidesmus indicus R. Br.) is widely used in Indian traditional medicine. In th...
Proteasome inhibition represents an important anticancer strategy. Here, we studied the mechanisms a...
The research of new botanicals is an important aspect of the modern research focused on prevention a...
Background: Although cancers are characterized by the deregulation of multiple signalling pathways, ...
The ability of anticancer treatments to promote the activation of tumor-reactive adaptive immune res...