Nucleic acid oxidation plays an important role in the pathophysiology progress of a variety of diseases. 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dGsn) and 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn), which originate from DNA and RNA oxidation, were the most widely used indicators for oxidative stress. The study investigated the relation between 8-oxo-dGsn, 8-oxo-Gsn, and CKD. 146 patients with CKD were divided into five disease stages, and their fasting blood and morning urine were collected. The levels of 8-oxo-dGsn and 8-oxo-Gsn in plasma and urine were quantified by LC-MS/MS. The ratio of urinary 8-oxo-Gsn to creatinine increased from stages 1 to 4 corresponding to the increased severity of CKD, but it decreased in stage 5. And plasma 8-ox...
Oxidative stress (OS), defined as disturbances in the pro-/antioxidant balance, is harmful to cells ...
This study was aimed at defining the reference ranges for biomarkers of oxidized guanine in (2'-deox...
Chronic kidney disease (CKD) is a common and serious problem that adversely affects human health, li...
<div><p></p><p>We used a sensitive and accurate method based on isotope dilution high-performance li...
OBJECTIVEdWe recently showed that RNA oxidation, estimated by urinary excretion of 8-oxo-7,8-dihydro...
A reliable and fast liquid chromatography-tandem mass spectrometry method has been developed for the...
Increased oxidative stress induced by hyperglycemia may contribute to the pathogenesis of diabetic c...
Background: Cardiovascular complications are the leading cause of morbidity and mortality at any sta...
Introduction: Markers of oxidative stress increase with age and are prevalent with chronic kidney di...
A sensitive and specific assay aimed at measuring the oxidized nucleic acids, 8-oxoguanine (8-oxoGua...
Introduction: Markers of oxidative stress increase with age and are prevalent with chronic kidney di...
OBJECTIVEdWe analyzed data from a cohort of 1,381 newly diagnosed type 2 diabetic patients to test t...
The aim of this study was to evaluate the oxidative DNA damage, antioxidant activity, and effects of...
Oxidative stress is enhanced in correlation with renal dysfunction: Examination with the redox state...
Context: Kidney-related pathologies have increasing prevalence rates, produce a considerable financi...
Oxidative stress (OS), defined as disturbances in the pro-/antioxidant balance, is harmful to cells ...
This study was aimed at defining the reference ranges for biomarkers of oxidized guanine in (2'-deox...
Chronic kidney disease (CKD) is a common and serious problem that adversely affects human health, li...
<div><p></p><p>We used a sensitive and accurate method based on isotope dilution high-performance li...
OBJECTIVEdWe recently showed that RNA oxidation, estimated by urinary excretion of 8-oxo-7,8-dihydro...
A reliable and fast liquid chromatography-tandem mass spectrometry method has been developed for the...
Increased oxidative stress induced by hyperglycemia may contribute to the pathogenesis of diabetic c...
Background: Cardiovascular complications are the leading cause of morbidity and mortality at any sta...
Introduction: Markers of oxidative stress increase with age and are prevalent with chronic kidney di...
A sensitive and specific assay aimed at measuring the oxidized nucleic acids, 8-oxoguanine (8-oxoGua...
Introduction: Markers of oxidative stress increase with age and are prevalent with chronic kidney di...
OBJECTIVEdWe analyzed data from a cohort of 1,381 newly diagnosed type 2 diabetic patients to test t...
The aim of this study was to evaluate the oxidative DNA damage, antioxidant activity, and effects of...
Oxidative stress is enhanced in correlation with renal dysfunction: Examination with the redox state...
Context: Kidney-related pathologies have increasing prevalence rates, produce a considerable financi...
Oxidative stress (OS), defined as disturbances in the pro-/antioxidant balance, is harmful to cells ...
This study was aimed at defining the reference ranges for biomarkers of oxidized guanine in (2'-deox...
Chronic kidney disease (CKD) is a common and serious problem that adversely affects human health, li...