Objective Hemicastration is a unilateral orchiectomy to remove an injured testis, which can induce hormonal changes and compensatory hypertrophy of the remaining testis, and may influence spermatogenesis. However, the underlying molecular mechanisms are poorly understood. Here, we investigated the impact of hemicastration on remaining testicular function. Methods Prepubertal mice (age 24 days) were hemicastrated, and their growth was monitored until they reached physical maturity (age 72 days). Subsequently, we determined testis DNA methylation patterns using reduced representation bisulfite sequencing of normal and hemicastrated mice. Moreover, we profiled the testicular gene expression patterns by RNA sequencing (RNA-seq) to examine wheth...
Suboptimal environmental conditions during development can substantially alter the epigenome. Stable...
BACKGROUND: Endocrine disruptor chemicals elicit adverse health effects by perturbing nuclear recept...
Beyond the haploid genome, mammalian sperm carry a payload of epigenetic information with the potent...
AbstractAlthough round spermatid injection can be used to create progeny for males who do not produc...
Background: DNA methylation is an epigenetic modification involved in gene expression, genome stabil...
DNA methylation is involved in tissue-specific and developmentally regulated gene expression. Here, ...
AbstractThe development of germ cells is a highly ordered process that begins during fetal growth an...
The control of gene expression occurs at multiple levels one of which is controlled by epigenetic re...
<div><h3>Background</h3><p>Endocrine disruptor chemicals elicit adverse health effects by perturbing...
DNA methylation is involved in tissue-specific and developmentally regulated gene expression. Here, ...
Increased oxidative DNA damage is observed in sperm devoid of contact with accessory sex gland (ASG)...
Sex- and sequence-specific patterns of methylation of mammalian DNA are established during gametogen...
DNA methylation plays important roles in the production and functioning of spermatozoa. Recent studi...
Spermatogenesis is a highly complex cell differentiation process that is governed by unique transcri...
Epigenetic modifications, and methylation of histones in particular, dynamically change during sperm...
Suboptimal environmental conditions during development can substantially alter the epigenome. Stable...
BACKGROUND: Endocrine disruptor chemicals elicit adverse health effects by perturbing nuclear recept...
Beyond the haploid genome, mammalian sperm carry a payload of epigenetic information with the potent...
AbstractAlthough round spermatid injection can be used to create progeny for males who do not produc...
Background: DNA methylation is an epigenetic modification involved in gene expression, genome stabil...
DNA methylation is involved in tissue-specific and developmentally regulated gene expression. Here, ...
AbstractThe development of germ cells is a highly ordered process that begins during fetal growth an...
The control of gene expression occurs at multiple levels one of which is controlled by epigenetic re...
<div><h3>Background</h3><p>Endocrine disruptor chemicals elicit adverse health effects by perturbing...
DNA methylation is involved in tissue-specific and developmentally regulated gene expression. Here, ...
Increased oxidative DNA damage is observed in sperm devoid of contact with accessory sex gland (ASG)...
Sex- and sequence-specific patterns of methylation of mammalian DNA are established during gametogen...
DNA methylation plays important roles in the production and functioning of spermatozoa. Recent studi...
Spermatogenesis is a highly complex cell differentiation process that is governed by unique transcri...
Epigenetic modifications, and methylation of histones in particular, dynamically change during sperm...
Suboptimal environmental conditions during development can substantially alter the epigenome. Stable...
BACKGROUND: Endocrine disruptor chemicals elicit adverse health effects by perturbing nuclear recept...
Beyond the haploid genome, mammalian sperm carry a payload of epigenetic information with the potent...