1<p>As of 09/03/09. Number of bioassays in which the compound was tested/number in which the compound was active/number in which the compound has been confirmed as an inhibitor.</p
<p>Preliminary hit clustering was based on the EC50 value from the concentration-response curves of ...
Abstract: Many screening hits inhibit enzymes with steep dose-response curves, which are considered ...
Scoring the activity of compounds in phenotypic high-throughput assays presents a unique challenge b...
<p>All hit compounds identified were chemical clustered using pubchem finger prints. (A) The major c...
<p>(A) Plot of z-scores for each of the 2240 compounds subjected to the primary screen for ISRE acti...
<p>The examined test compounds for TS inhibition, their reference numbers, structures, and manufactu...
<p>The number of compounds found to demonstrate inhibition at 10μM overall and with respect to the t...
<p>Structures and PKD1 inhibitory activities of selected small molecule inhibitors identified in pre...
<p>A flow diagram of various assays used in the screen. The number of hits remaining after each run ...
<p>The number of distinct compound-target combinations screened in multiple assays, listed for incre...
<p>Surviving and eliminated compounds from the local (<i>left</i>) and BIPDeC (<i>right</i>) HTS's a...
<p>A) CGP-74514A, B) P2, C) P6, D) P7, E) P8 compared to no inhibitor (gray squares) or no enzyme (g...
<p><sup>a</sup>EC<sub>50</sub> values obtained against <i>T. cruzi</i> parasites in HTS assay used t...
<p>GST inhibitors tested in this study and their inhibitory activity against <i>Sj</i>GST.</p
<p><sup>a</sup>EC<sub>50</sub> values obtained against <i>T.cruzi</i> parasites in HTS assay used to...
<p>Preliminary hit clustering was based on the EC50 value from the concentration-response curves of ...
Abstract: Many screening hits inhibit enzymes with steep dose-response curves, which are considered ...
Scoring the activity of compounds in phenotypic high-throughput assays presents a unique challenge b...
<p>All hit compounds identified were chemical clustered using pubchem finger prints. (A) The major c...
<p>(A) Plot of z-scores for each of the 2240 compounds subjected to the primary screen for ISRE acti...
<p>The examined test compounds for TS inhibition, their reference numbers, structures, and manufactu...
<p>The number of compounds found to demonstrate inhibition at 10μM overall and with respect to the t...
<p>Structures and PKD1 inhibitory activities of selected small molecule inhibitors identified in pre...
<p>A flow diagram of various assays used in the screen. The number of hits remaining after each run ...
<p>The number of distinct compound-target combinations screened in multiple assays, listed for incre...
<p>Surviving and eliminated compounds from the local (<i>left</i>) and BIPDeC (<i>right</i>) HTS's a...
<p>A) CGP-74514A, B) P2, C) P6, D) P7, E) P8 compared to no inhibitor (gray squares) or no enzyme (g...
<p><sup>a</sup>EC<sub>50</sub> values obtained against <i>T. cruzi</i> parasites in HTS assay used t...
<p>GST inhibitors tested in this study and their inhibitory activity against <i>Sj</i>GST.</p
<p><sup>a</sup>EC<sub>50</sub> values obtained against <i>T.cruzi</i> parasites in HTS assay used to...
<p>Preliminary hit clustering was based on the EC50 value from the concentration-response curves of ...
Abstract: Many screening hits inhibit enzymes with steep dose-response curves, which are considered ...
Scoring the activity of compounds in phenotypic high-throughput assays presents a unique challenge b...