Graphic representation of the relative caspase-3 activity of SAOS-2 cells exposed to CDDP after growth stimulation in simulated hypogravity.

<p>SAOS-2 cells grown for 5 days in the hydrofocusing bioreactor and treated with 10 µg/mL of CDDP die by apoptosis as evidenced by a caspases-3 colorimetric assay. The white bar illustrates the caspase-3 activity recovered from SAOS-2 cells grown in the HFB and then treated with CDDP for 24-hours. The black bar illustrates the caspase-3 activity recovered from SAOS-2 cells grown in static normal (1-G) condition and then treated with CDDP for 24-hours, and the grey bar indicates the basal caspases-3 activity of SAOS-2 cells grown in static 1-G condition.