Chronic <i>in vivo</i> imaging in adult mice reveals improvements in ipsilateral retinotopic maps after monocular enucleation (ME) of the contralateral eye.

<p>(A, upper panel) Example scatter maps from the same animal show a reduction in scatter values after ME. (A, lower panel) Cumulative histogram of the two maps shown in the upper panel shows a leftward shift after ME, indicating more low scatter pixels in the retinotopic map. (B) Group data show that scatter values do not decrease immediately, but decrease 30% during the third week after ME (late post ME). (C, upper panel) Outlines of responsive cortex for the three pre ME time points and the three late post ME time points in the same animal overlap each other indicating little change in the area or location of responsive cortex. The outlines were aligned using vascular images. (C, lower panel) Change in scatter is plotted versus the change in area of responsive cortex showing that scatter values consistently decrease (points lie below the horizontal line) while no trend in area changes is observed (points evenly distributed on either side of the vertical line). Data from the example animal is colored black. (D) Group data show that the area of responsive cortex does not change after ME. (E, upper panel) Example magnitude maps show responsiveness before ME and during the third week after ME (late post ME). (E, lower panel) Change in scatter is plotted versus the change in maximum response magnitude showing that scatter values consistently decrease (points lie below the horizontal line) while maximum response magnitude consistently increases (points lie to the right of the vertical line). Data from the example animal is colored black. (F) Group data show that maximum response magnitude increases 30% during the third week after ME (late post ME). Reported p-values were computed using a paired, two-tailed t-test.