Terminal Schwann cells in transplanted adult muscle are derived from the host.

<p>A. Low magnification view of a wild-type MG muscle transplanted 2 months earlier into a transgenic mouse that expresses EGFP (green) under the direction of the S100 promoter. Endplate ACHRs are stained with α−Btx (red). This panel illustrates the general finding that all endplate staining colocalized with EGFP. B. EGFP fluorescence was absent at motor endplates in an MG muscle from an EGFP-expressing transgenic transplanted into a wild-type host (B1) but the same endplates stained positively for S100 (green, B2), demonstrating that terminal Schwann cells were derived from the host. C. To exclude the possible survival of wild-type TSCs after transplantation of wild-type muscle into the ECFP transgenic (C1), muscle sections were first labeled for S100 (C2) but all labeling was found to colocalize with EGFP fluorescence (C3) providing further evidence that wild-type TSCs did not survive transplantation.